He was playing with Nigerian Concord FC when he moved to Switzerland in 1995 signing with AC Bellinzona. Between 1996 and 1998 he played with Slovenian FC Koper and Cypriot Enosis Neon Paralimni FC before signing with Italian A.C. Reggiana 1919. After that short spell in Italy he moved to Russia. He made his debut in the Russian Premier League in 1998 for FC Dynamo Moscow. He played 4 games in the UEFA Cup 1998–99 for FC Dynamo Moscow. According to a 2004 interview with a fellow Nigerian footballer James Obiorah Isibor had AIDS and according to some later reports, he died on January 8, 2006. However, according to former Isibor’s teammate Aleksandr Tochilin, another former Dynamo player Patrick Ovie met Isibor in Nigeria after his supposed death and Isibor was healthy and well. He died on June 24, 2013 in Lagos, Nigeria, after a brief illness. Afterwards he also played in South Korean K-League club Suwon Samsung Bluewings and Swiss FC Zürich. He was HIV-positive.